Spanish · Pronunciation Guide
kyen, one syllable — silent u, and the ie glides into a single beat.
One syllable, so the accent cannot be assigning stress within the word — it marks the interrogative, exactly as it does in "qué" and "cuál". The plural "quiénes" adds a syllable and keeps the accent, this time genuinely holding the beat on QUIÉ against what the default rule would do.
Listen: quién
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¿Quién habla?
Who's speaking?
Listen: ¿Quién habla?
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"¿Quién habla?" is what you say when answering the phone in Spanish, and it literally asks who is speaking. "Habla" has a silent h and a soft b between vowels, so the two words run together as kyen-AB-la. The rising question intonation carries the whole sentence.
English spelling instincts produce two errors in a single syllable: a voiced u, giving "kwyen", and a split ie, giving "kee-EN". Both come from English spelling instincts. It is one compact beat: k plus a y glide plus "ehn". And note that "quién" never varies for gender but does for number — asking about several people takes "quiénes", which learners routinely forget.