Portuguese (Brazil) · Pronunciation Guide
KEE. The u is completely silent — it's there only to keep the q hard — and the e raises to an i.
As a relative pronoun or conjunction, "que" is unstressed and leans onto the clause it introduces, which is what keeps its vowel raised to i. Its accented sibling "quê" — used at the end of a question, as in "por quê?" — is stressed and takes a closed "ay" instead, so the accent mark is signalling a genuine sound change.
Listen: que
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Ela disse que vem.
She said she's coming.
Listen: Ela disse que vem.
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"Ela disse que vem" hangs a whole subordinate clause off this one syllable. "Disse" has a raised final e giving "DJEE-see," and "vem" is a nasal "veyng" with no closing consonant. Between them, "que" is barely more than a quick "kee" — Brazilians speed through it, and learning to skip lightly over it is part of sounding fluent.
Beginners pronounce the u, producing "kweh," which is what the letters suggest to an English eye and what a Spanish speaker's habits reinforce for "qué." There's no w sound here at all. The second issue is holding the word too long: because it's grammatically important, learners give it weight, but native speakers reduce it almost to nothing between the words that matter.